Image of equipment used in microbial fermentation development processes by Scorpion

Process Development

Microbial Fermentation Development

Scorpion’s process development staff has extensive experience optimizing microbial fermentation batch and fed-batch processes for the production of protein biologics, therapeutic enzymes and plasmid DNA at our CDMO biomanufacturing facility. We utilize an expandable, benchtop, single-use, stirred bioreactor system for statistical design of experiments (DOE) and process optimization studies.

Service Offerings
  • E. coli recombinant expression platforms to produce therapeutic proteins and plasmid DNA
  • Use of Process Excellence Six Sigma methodology (e.g., Design of Experiments) for the optimization of upstream fermentation processes
  • Application of QbD principles throughout development
  • Identification of important process parameters via FMEA analysis
  • Processes scalable from bench scale to 100L
  • Use of advanced cell culture process control strategies
  • Process monitoring capabilities including metabolic profile analysis
  • Optimization of cell lysis (mechanical vs. chemical)
  • Optimization of cell harvest separation process
  • Scale-down validation studies
Image of equipment used in microbial fermentation development processes by Scorpion

Scorpion’s process development staff has extensive experience optimizing microbial fermentation batch and fed-batch processes for the production of protein biologics, therapeutic enzymes and plasmid DNA. We utilize an expandable, benchtop, single-use, stirred bioreactor system for statistical design of experiments (DOE) and process optimization studies.