header_discovery@2x

Discovery Research & Product Development Services

Scorpius BioManufacturing offers clients in the early stages of product development a customized and integrated end-to-end solution for their large molecule and biologics discovery research, process and analytical methods development, cGMP manufacturing, product characterization and QC release testing needs. Our approach enables us to forge collaborative client relationships that move beyond the traditional service outsourcing model into full product development collaborations.

Our discovery team engages in cutting-edge research with expertise in cell biology, molecular biology, protein engineering, antibody discovery, protein expression, computational analysis and more. Scorpius' discovery services are enhanced by bioinformatics capabilities that enable faster, more efficient target identification and validation.

Precision Therapeutics Capabilities

In addition, Scorpius also has a powerful and multifaceted platform for the development of next-generation precision therapeutics with an exceptional ability to dissect, identify and define the essential pharmacological domains of any protein-protein interaction. Through using this platform, Scorpius BioManufacturing can validate known and unknown targets and generate novel drug candidates.

Scorpius' Discovery Capabilities

Scorpius offers a range of discovery research services for those seeking to enter the first phase of large molecule or biologics manufacturing. Our robust discovery capabilities include: 

Molecular Biology

  • Phage display identification of peptide/antibody-based agonists or antagonists for any target
  • DNA sequencing and analysis
  • cDNA library construction
  • Gene cloning/subcloning
  • PCR and RT-qPCR
  • Vector optimization

Protein Expression Systems

  • Mammalian expression in HEK293, 3T3 and CHO cell lines
  • Bacterial expression in E. coli

Bench-Scale Protein Purification

  • Protein purification using epitope tags and affinity chromatography (e.g., 6XHis, Myc, Protein A, Protein G, Protein A/G)
  • SDS-PAGE and Western analysis

Protein Engineering

  • DNA-based optimization of peptides, proteins and antibodies
  • Identification of protein-based agonists and antagonists
  • Protein design/directed evolution
  • Epitope mapping

Computational Analysis

  • Identification of target pathways
  • Target prioritization and ranking
  • Target validation
  • Predictive protein-protein interactions
Cell Biology
  • Tissue culture

  • Development of stable, gene-expressing cell lines

  • Development of functional cell-based assays

  • ELISA

  • Immunofluorescence

  • Flow cytometry

Want to learn more about our discovery research and product development services?
Let’s discuss your
needs.
contact_us_cta